Genetic Engineering and Human Health

CONTENTS OF CURRICULUM UNIT 13.06.01

  1. Unit Guide
  1. Introduction
  2. Rationale
  3. The Human Cell: Anatomy and Function
  4. Organelles
  5. DNA Structure
  6. Genes
  7. The Central Dogma of Biology
  8. Proteins
  9. DNA Replication
  10. Chromosomes
  11. Heredity
  12. Genetic Disorders
  13. Gene Therapy
  14. Classroom Activities
  15. Bibliography
  16. Websites Resources
  17. Appendix
  18. Notes

Imagine the Unimaginable Harnessing the Power of DNA: Principles of Genetic Engineering

Laura Ann Carroll-Koch

Published September 2013

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Heredity

Heredity is the manner in which genetic traits are passed on to the next generation.

Chromosomes are the means through which the genetic material is transferred. The process of meiosis makes a sex cell or gametes, which holds just one set of a parent's chromosomes twenty-two plus a sex chromosome. During sexual reproduction, both sets of chromosomes are joined when the egg is fertilized by the sperm. Fertilization combines the genetic material from both parents, fusing to form a zygote, the first cell of a new individual. 23 As a result, the offspring has the combined genetic material of both parents. Consequently, each cell will have a pair of each chromosome, which results in a pair of genes for each trait. The positions of the two genes on the chromosome are alleles, or one's genotype. One allele is often dominant over the other. The dominant allele is expressed and can often be observed as physical trait, like eye color, right or left handedness, freckles, and curly hair. The observable trait is called one's phenotype, on the other hand, an unexpressed trait is called a recessive gene. We inherit many different traits including physical, behavioral, and predispositions to medical conditions like sickle-cell anemia, cystic fibrosis, heart disease, cancer, and some mental illnesses. 24

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