Manipulating Biology: Costs, Benefits and Controversies

CONTENTS OF CURRICULUM UNIT 18.05.10

  1. Unit Guide
  1. Introduction
  2. The History of Vaccines
  3. The Germ Theory of Disease
  4. Benefits of Vaccines
  5. Costs
  6. Controversies
  7. Content Objectives
  8. Strategies
  9. Activities
  10. Appendix
  11. Bibliography
  12. Endnotes

Vaccines and the Outbreak of Nonsense

Thomas L. Teague

Published September 2018

Tools for this Unit:

Bibliography

"10 Facts on Polio Eradication." World Health Organization. March 14, 2018. Accessed July 16, 2018. http://www.who.int/features/factfiles/polio/en/.

Author, Contributing. "Louis Pasteur, Spontaneous Generation, and Germ Theory." ZME Science. May 12, 2016. Accessed July 15, 2018. https://www.zmescience.com/other/feature-post/louis-pasteur-spontaneous-generation-germ-theory/.

Bronfin, Daniel R., MD. "Childhood Immunization Controversies: What Are Parents Asking?" The Ochsner Journal 8, no. 3 (2008): 151-56. Accessed July 13, 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096324/.

Answers a number of common questions parents might have regarding vaccination. Covers the basics of vaccine effectiveness in introduction.

Dayton, Kels. "More Federal Funding Approved for Universal Flu Vaccine." WTNH. March 23, 2018. Accessed July 16, 2018. https://www.wtnh.com/news/health/more-federal-funding-approved-for-universal-flu-vaccine_2018040310402149/1097764975.

"Edward Jenner and the Development of the Smallpox Vaccine." Books, Health and History. May 13, 2016. Accessed July 14, 2018. https://nyamcenterforhistory.org/2016/05/13/edward-jenner-and-the-development-of-the-smallpox-vaccine/.

Narrative of Jenner's vaccination breakthrough with images.

"Germ Theory." Open Collections Program: Contagion, The Yellow Fever Epidemic in Philadelphia, 1793. Accessed July 14, 2018. http://ocp.hul.harvard.edu/contagion/germtheory.html.

Overview of the discovery and adoption of germ theory and its link to disease.

"Global Alliance for Vaccines and Immunization (GAVI)." World Health Organization. November 22, 2010. Accessed July 16, 2018. http://www.who.int/mediacentre/factsheets/fs169/en/.

Up to date statistics about lives saved from vaccination, as well as information about the impacts of vaccines not being universally available in poorer regions of the world.

Harris, William. "How the Scientific Method Works." HowStuffWorks Science. March 08, 2018. Accessed July 15, 2018. https://science.howstuffworks.com/innovation/scientific-experiments/scientific-method5.htm.

Explanation of the scientific method using Pasteur's experiment on spontaneous generation as an example. Includes images.

"History of Anti-vaccination Movements." History of Vaccines. Accessed July 16, 2018. https://www.historyofvaccines.org/content/articles/history-anti-vaccination-movements.

Great, in depth information about the early history of the anti-vaccine movements in the United States & United Kingdom.

"Investment in Research Saves Lives and Money." Research America. 2016. https://www.researchamerica.org/sites/default/files/Vaccine Fact Sheet_2016.pdf.

Light, Donald W., and Rebecca Warburton. "Demythologizing the High Costs of Pharmaceutical Research." BioSocieties 6, no. 1 (2011): 34-50. doi:10.1057/biosoc.2010.40.

Louten, Jennifer, Ph.D. Essential Human Virology. Elsevier Science Publishing, 2016.

Miller, Henry I. "We're Underfunding Research on Vaccines That May Be Able to Prevent Another Terrible Flu Season." Los Angeles Times. January 19, 2018. Accessed July 16, 2018. http://www.latimes.com/opinion/op-ed/la-oe-miller-flu-vaccines-could-be-more-effective-20180119-story.html.

MPH, Jonathan D. Quick MD, and Heidi Larson. "The Vaccine-Autism Myth Started 20 Years Ago. Here's Why It Endures Today." Time. February 28, 2018. Accessed July 16, 2018. http://time.com/5175704/andrew-wakefield-vaccine-autism/.

Pitt, Dennis, and Jean-Michel Aubin. "Joseph Lister: Father of Modern Surgery." Advances in Pediatrics. October 2012. Accessed July 15, 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468637/.

Leung, Angela Ki Che. History of Vaccine Development. Edited by Stanley A. Plotkin. New York: Springer, 2011.

This book is a compendium of chapters written by different authors covering a number of topics in the history of vaccination.

Baxby, Derrick. History of Vaccine Development. Edited by Stanley A. Plotkin. New York: Springer, 2011.

Covers Edward Jenner’s Role in the Introduction of Smallpox Vaccine

Rao, T. S. Sathyanarayana, and Chittaranjan Andrade. "The MMR Vaccine and Autism: Sensation, Refutation, Retraction, and Fraud." Advances in Pediatrics. 2011. Accessed July 16, 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136032/.

"Robert Koch - Biographical." Nobelprize.org. Accessed July 15, 2018. https://www.nobelprize.org/nobel_prizes/medicine/laureates/1905/koch-bio.html.

"Smallpox." World Health Organization. January 13, 2014. Accessed July 14, 2018. http://www.who.int/biologicals/vaccines/smallpox/en/.

Statistics on smallpox, background about vaccine development by Jenner.

"Smallpox." Emergencies Preparedness, Response. May 02, 2018. Accessed July 14, 2018. http://www.who.int/csr/disease/smallpox/en/.

Smith, David R., M.D.. The Promise of Vaccines: The Science and the Controversy. New York, NY: American Council on Science and Health, 2001.

Useful history, statistics, and explanation of different types of vaccines.

Stevenson, Lloyd Grenfell. "Robert Koch." Encyclopædia Britannica. May 25, 2018. Accessed July

15, 2018. https://www.britannica.com/biography/Robert-Koch#ref700442.

Overview of Koch's career, including his famous postulates.

"Vaccine Delivery." Bill & Melinda Gates Foundation. Accessed July 16, 2018.

https://www.gatesfoundation.org/What-We-Do/Global-Development/Vaccine-Delivery.

"Vaccines & Immunizations." Centers for Disease Control and Prevention. March 10, 2017.

Accessed July 16, 2018. https://www.cdc.gov/vaccines/vac-gen/whatifstop.htm.

"Vaccines Bring 7 Diseases under Control." UNICEF. Accessed July 16, 2018.

https://www.unicef.org/pon96/hevaccin.htm.

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