Genetic Engineering and Human Health

CONTENTS OF CURRICULUM UNIT 13.06.07

  1. Unit Guide
  1. Introduction & Background
  2. Rationale
  3. DNA Biology
  4. DNA in Forensic Science
  5. Polymerase Chain Reaction
  6. Gel Electrophoresis
  7. Strategies and Classroom Activities
  8. Bibliography
  9. Teacher Resources Bibliography
  10. Appendix 1
  11. Appendix 2
  12. Appendix 3
  13. Appendix 4
  14. Appendix 5
  15. Notes

DNA in Forensic Science: genetic engineering applications in forensics

Vanessa Vitug

Published September 2013

Tools for this Unit:

Bibliography

Bowen, R.. "Agarose Gel Electrophoresis of DNA." Biotechnology and Genetic Engineering. http://arbl.cvmbs.colostate.edu/hbooks/genetics/biotech/gels/agardna.html (accessed July 14, 2013). Section related to use of agarose use was helpful.

Butler, John M.. "DNA Biology Review." In Forensic DNA typing biology, technology, and genetics of STR markers. 2nd ed. Amsterdam: Elsevier Academic Press, 2005. 36-50. Great overview of DNA Biology with a broad range of topics and some depth.

Butler, John M.. Forensic DNA typing biology, technology, and genetics of STR markers. 2nd ed. Amsterdam: Elsevier Academic Press, 2005. Great overview of DNA Biology with a broad range of topics and some depth.

Butler, John M., Michael D. Coble, and Peter M. Vallone. "STRs Vs. SNPs: Thoughts On The Future Of Forensic DNA Testing." Forensic Science, Medicine, and Pathology 3, no. 3 (2007): 200-205. Good for background on SNPS.

"Chelex® 100 Extraction Process." National Forensic Science Technology Center . http://www.nfstc.org/pdi/Subject03/pdi_s03_m03_01.htm (accessed July 28, 2013). A guide to Chelex's use.

Clark, David P.. "The Polymerase Chain Reaction." In Molecular Biology Understanding the Genetic Revolution.. Burlington: Elsevier, 2005. 634-654. PCR in detail.

"DNA Evidence: Basics of Analyzing | National Institute of Justice." National Institute of Justice: Criminal Justice Research, Development and Evaluation. http://www.nij.gov/topics/forensics/evidence/dna/basics/analyzing.htm (accessed June 21, 2013). Background on the use of DNA as evidence.

"DNA Identification in Mass Fatality Incidents." President's DNA Initiative. http://massfatality.dna.gov/Chapter2/ (accessed May 13, 2013). Describe the beginning of collecting DNA information due to mass fatality incidents.

"DNA Technology - The science behind DNA testing." DNA Junction - Your resource for DNA testing information. http://www.dnajunction.com/technology/ (accessed June 27, 2013). Source for DNA testing uses, but not for background information.

"DNA Timeline: DNA Science from Mendel to Today." DNA Interactive: Discovering the DNA Structure and beyond. http://www.dnai.org/timeline/ (accessed June 22, 2013). Good site for student and teachers gives a wide scope and sequences DNA through time.

"DNA-RNA-Protein." Nobelprize.org. http://www.nobelprize.org/educational/medicine/dna/b/translation/translation.html (accessed June 23, 2013). Detailed overview of the Central Dogma.

"DNA.gov: Types of DNA Samples Suitable for Testing." The DNA Initiative. http://www.dna.gov/basics/analysis/types-of-samples (accessed June 21, 2013). National Institute of Justice site for DNA used in criminal cases.

Saltzman, Mark. "Genetic Engineering ." Seminar Discussion, Intensive Session from Yale National Initiative, New Haven, July 10, 2013.

Hayes, Molly, and Frieda Reichsman. "DNA Forensics." In DNA and biotechnology. 3rd ed. Burlington, MA: Academic Press/Elsevier, 2010. 173-190. Background on genetic principles used in biotech.

Houck, Max M., and Jay A. Siegel. "DNA Analysis." In Fundamentals of forensic science. Amsterdam: Elsevier/Academic Press, 2006. 265-293. Sections of the book are particularly helpful in giving chemistry, biology background as related to forensics.

Houck, Max M., and Jay A. Siegel. "Electrophoresis." In Fundamentals of forensic science. Amsterdam: Elsevier/Academic Press, 2006. 149-152. Sections of the book are particularly helpful in giving chemistry, biology background as related to forensics.

Roche. "How PCR Works." Roche Molecular Diagnostics - IVD Assays and Instruments. http://molecular.roche.com/About/pcr/Pages/PCRProcess.aspx (accessed July 13, 2013). PCR specifically as used at Roche.

Jobling, Mark A., and Peter Gill. "Encoded Evidence: DNA In Forensic Analysis." Nature Reviews Genetics 5, no. 10 (2004): 739-751. Short article giving basic overview of DNA forensics.

Kirby, Lorne T.. "DNA Amplification." In DNA fingerprinting: an introduction. New York: Stockton Press, 1990. 1-16. Good information but dated

Kirby, Lorne T.. "Genetic Principles." In DNA fingerprinting an introduction. New York: Oxford University Press, 1993. 7-33. Basic but dated information.

MacPherson, M. J., and S. G. Møller. "Understanding PCR." In PCR. repr ed. Oxford: BIOS, 2003. 21-33. Overview of PCR and its purpose.

Morling, Niels. "PCR In Forensic Genetics." Biochemical Society Transactions 37, no. 2 (2009): 438. Article specifying use of DNA in forensics.

"Mount Pleasant High - Reports (CA Dept of Education)." DataQuest (CA Dept of Education). http://data1.cde.ca.gov/dataquest/DQReports.asp?CDSType=S&CDSCode=43694274334900 (accessed June 22, 2013).School data source.

Mount Pleasant. "Ed-Data Website." Ed-Data. http://www.ed-data.k12.ca.us/App_Resx/EdDataClassic/fsTwoPanel.aspx?#!bottom=/_layouts/EdDataClassic//profile.asp?Level=07&County=43&district=69427&school=4334900&reportnumber=16 (accessed June 22, 2013). School data resource.

Nicholl, Desmond S. T.. An introduction to genetic engineering. 1994. Reprint, Cambridge [England: Cambridge University Press, 2008.

Saltzman, W. Mark. "Biomolecular Principles: Nucleic Acids." In Biomedical engineering bridging medicine and technology. Cambridge: Cambridge University Press, 2009. 93-107. Text is a good overview of genetic principles/

"School Enrollment by Ethnicity - Enrollment by Ethnicity for 2012-13." DataQuest (CA Dept of Education). http://data1.cde.ca.gov/dataquest/Enrollment/EthnicEnr.aspx?cType=ALL&cGender=B&cYear=2012-13&Level=School&cSelect=MT%2E+PLEASANT+HIGH—EAST+SIDE+UNION—4369427-4334900&cChoice=SchEnrEth (accessed June 23, 2013). Information for MPHS and other high school data needed.

Sobrino, B, M Brion, and A Carracedo. "SNPs In Forensic Genetics: A Review On SNP Typing Methodologies." Forensic Science International 154, no. 2-3 (2005): 181-194. Discusses benefits and limitations of SNP typing.

"The Innocence Project - Home." The Innocence Project - Home. http://www.innocenceproject.org/ (accessed June 13, 2013). Resource for criminal cases overturned by new DNA information.

"What Is A Gene? | TechNyou." Welcome to TechNyou science education resources. | TechNyou. http://education.technyou.edu.au/view/91/94/what-gene (accessed June 28, 2013). Website useful for a variety of information from genetic engineering, GMOs, and stem cells.

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