Manipulating Biology: Costs, Benefits and Controversies

Notes

1. Kalueff et al., “Zebrafish as an Emerging Model for Studying Complex Brain Disorders.”
2. Jones and Norton, “Using Zebrafish to Uncover the Genetic and Neural Basis of Aggression, a Frequent Comorbid Symptom of Psychiatric Disorders.”
3. Kalueff et al., “Zebrafish as an Emerging Model for Studying Complex Brain Disorders”; Jones and Norton, “Using Zebrafish to Uncover the Genetic and Neural Basis of Aggression, a Frequent Comorbid Symptom of Psychiatric Disorders.”
4. Gara et al., “Influence of Patient Race and Ethnicity on Clinical Assessment in Patients with Affective Disorders”; Kirkbride et al., “Incidence of Schizophrenia and Other Psychoses in England, 1950–2009: A Systematic Review and Meta-Analyses.”
5. S.M. et al., “Ethnicity and Diagnosis in Patients with Affective Disorders”; Arnold et al., “Ethnicity and First-Rank Symptoms in Patients with Psychosis.”
6. Perlman et al., “Symptoms of Psychosis in Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder: A Comparison of African Americans and Caucasians in the Genomic Psychiatry Cohort.”
7. Monosson, “Epigenetics: Epilogue or Prologue?”
8. Cunliffe, “The Epigenetic Impacts of Social Stress: How Does Social Adversity Become Biologically Embedded?”
9. Sullivan, Kendler, and Neale, “Schizophrenia as a Complex Trait - Evidence from a Meta- Analysis of Twin Studies.”
10. Bruist, “A Simple Demonstration of How Intermolecular Forces Make DNA Helical.”
11. Zhuo et al., “Genomic Editing of Non-Coding RNA Genes with CRISPR/Cas9 Ushers in a Potential Novel Approach to Study and Treat Schizophrenia.”
12. Seed, “Battling Phages: How Bacteria Defend against Viral Attack.”
13. Deverman et al., “Cre-Dependent Selection Yields AAV Variants for Widespread Gene Transfer to the Adult Brain.”
14. Barrangou and Horvath, “A Decade of Discovery: CRISPR Functions and Applications.”
15. Barrangou et al., “CRISPR Provides Acquired Resistance Against Virses in Prokaryotes.”
16. Charlesworth et al., “Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans.”
17. Anders et al., “Europe PMC Funders Group Structural Basis of PAM-Dependent Target DNA Recognition by the Cas9 Endonuclease”; Sternberg et al., “DNA Interrogation by the CRISPRRNA-Guided Endonuclease Cas9.”
18. Nelson et al., “In Vivo Genome Editing Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy.”
19. Ho et al., “Targeting Non-Coding RNAs with the CRISPR/Cas9 System in Human Cell Lines.”
20. Zhuo et al., “Genomic Editing of Non-Coding RNA Genes with CRISPR/Cas9 Ushers in a Potential Novel Approach to Study and Treat Schizophrenia.”
21. Shin et al., “CRISPR/Cas9 Targeting Events Cause Complex Deletions and Insertions at 17 Sites in the Mouse Genome.”
22. Saey, “Resistance to CRISPR Gene Drives May Arise Easily.”
23. Noble et al., “Current CRISPR Gene Drive Systems Are Likely to Be Highly Invasive in Wild Populations.”
24. Kleinstiver et al., “Engineered CRISPR-Cas9 Nucleases with Altered PAM Specificities.”
25. Kleinstiver et al.
26. “Black Lightning (2018) Episode Scripts | SS.”
27. Kowalski, “Can DNA Editing Save Endangered Species?”; Saey, “New Tools Can Fix Genes One Letter at a Time”; Saey, “Molecular Scissors Fix Disease-Causing Flaw in Human Embryos”; Zielinski, “Even Some Olympic Athletes Cheat with Drugs”; Saey, “Gene Editing Swats at Mosquitoes”; Saey, “Expert Panel Approves Human Gene Editing”; Saey, “Gene Editing Creates Buff Beagles”; Thompson, “Scientists Hide a Real Movie within a Germ’s DNA.”
28. Hamers, “Cancer Cells Engineered with CRISPR Slay Their Own Kin”; Saey, “Researchers Say CRISPR Edits to a Human Embryo Worked. But Critics Still Doubt It”; Saey, “Most Americans Think It’s OK to Tweak a Baby’s Genes to Prevent Disease.”
29. Wanet et al., “MiR-212/132 Expression and Functions: Within and beyond the Neuronal Compartment”; Pan et al., “MiR-137 Inhibited Cell Proliferation and Migration of Vascular Smooth Muscle Cells via Targeting IGFBP-5 and Modulating the MTOR/STAT3 Signaling”; Liu et al., “MicroRNA-138 Suppresses Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma Cell Lines.”; Zhuo et al., “Genomic Editing of Non-Coding RNA Genes with CRISPR/Cas9 Ushers in a Potential Novel Approach to Study and Treat Schizophrenia.”