Appendix
Standards – Annotated
Pennsylvania Department of Education: Standards Aligned System
Standard - 3.1.B.B3: Describe the basic structure of DNA, including the role of hydrogen bonding. Explain how the process of DNA replication results in the transmission and conservation of the genetic code. Describe how transcription and translation result in gene expression. Cite evidence to support that the genetic code is universal.
This unit addresses how RNA are responsible for the regulation for genes and how RNA molecules can be used to repair DNA.
Standard - 3.1.C.B3: Describe the structure of the DNA and RNA molecules.
Standard - 3.1.C.C2: Use molecular models to demonstrate gene mutation and recombination at the molecular level.
The unit focuses on how a protein originally discovered in bacteria could create a way for humans to repair genetic mutations at precise locations.
Standard - 3.2.C.A2: Draw Lewis dot structures for simple molecules and ionic compounds.
Predict the chemical formulas for simple ionic and molecular compounds.
Common Core Standards for Science and Technical Subjects
RST.11-12.1 Cite specific textual evidence to support analysis of science and technical texts, attending to important distinctions the author makes and to any gaps or inconsistencies in the account.
WHST.9-12.9 Draw evidence from informational texts to support analysis, reflection, and research.
Next Generation Science Standards
HS-PS2-6. Communicate scientific and technical information about why the molecular-level structure is important in the functioning of designed materials.
This standard is implemented in the lesson in which students must learn the role of the Cas9 nuclease and determine where the nuclease would alter DNA given an miRNA sequence as guide RNA.
HS-LS1-1. Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells.
This unit actually addresses the idea of using RNA and proteins to reverse engineer DNA.
HS-LS3-2. Make and defend a claim based on evidence that inheritable genetic variations may result from: (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors.
This unit will examine errors during replication when learning the role of the Cas9 nuclease and discuss environmental factors that could cause mutations during the classroom discussion about science facts and fiction in the Black Lightning television series.
Comments: